Effect of Linker Stereochemistry on the Activity of Indolinobenzodiazepine Containing Antibody–Drug Conjugates (ADCs)

[Image: see text] Antibody–drug conjugates (ADCs) that incorporate potent indolinobenzodiazepine DNA alkylators as the payload component are currently undergoing clinical evaluation. In one ADC design, the payload molecules are linked to the antibody through a peptidase-labile l-Ala-l-Ala linker. In...

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Udgivet i:ACS Med Chem Lett
Main Authors: Reid, Emily E., Archer, Katie E., Shizuka, Manami, Wilhelm, Alan, Yoder, Nicholas C., Bai, Chen, Fishkin, Nathan E., Harris, Luke, Maloney, Erin K., Salomon, Paulin, Hong, Erica, Wu, Rui, Ab, Olga, Jin, Shan, Lai, Katharine C., Sikka, Surina, Chari, Ravi V. J., Miller, Michael L.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691565/
https://ncbi.nlm.nih.gov/pubmed/31413805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00240
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