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Expanded Utility of the β-Glucuronide Linker: ADCs That Deliver Phenolic Cytotoxic Agents
[Image: see text] The β-glucuronide linker has been used for antibody−drug conjugates (ADCs) to deliver amine-containing cytotoxic agents. The linker is stable in circulation, hydrophilic and provides ADCs that are highly active in vitro and in vivo. To extend the utility of the β-glucuronide linker...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Chemical Society
2010
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4007898/ https://ncbi.nlm.nih.gov/pubmed/24900208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100039h |
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