DOCK8 deficiency diminishes thymic T‐regulatory cell development but not thymic deletion

OBJECTIVE: To define the effect of DOCK8 deficiency on thymic tolerance in mice. METHODS: Thymocytes from wild‐type (Dock8(+/+)) and DOCK8‐deficient (Dock8(pri/pri)) mice were examined by flow cytometry. Some mice had transgenic expression of the BCL2 anti‐apoptotic protein in haemopoietic cells. So...

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Bibliographic Details
Published in:Clin Transl Immunology
Main Authors: Randall, Katrina L, Law, Hsei Di, Ziolkowski, Andrew F, Wirasinha, Rushika C, Goodnow, Christopher C, Daley, Stephen R
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
Subjects:
Short Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790591/
https://ncbi.nlm.nih.gov/pubmed/33437483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cti2.1236
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