Delayed control of herpes simplex virus infection and impaired CD4(+) T cell migration to the skin in mouse models of DOCK8 deficiency

DOCK8 deficiency in humans and mice leads to multiple defects in immune cell numbers and function. Patients with this immunodeficiency have a high morbidity and mortality, and are distinguished by chronic, cutaneous viral infections, including those caused by herpes simplex virus (HSV). The underlyi...

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Bibliographic Details
Published in:Immunol Cell Biol
Main Authors: Flesch, Inge EA, Randall, Katrina L, Hollett, Natasha A, Law, HseiDi, Miosge, Lisa A, Sontani, Yovina, Goodnow, Christopher C, Tscharke, David C
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496291/
https://ncbi.nlm.nih.gov/pubmed/25776845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2015.32
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