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Delayed control of herpes simplex virus infection and impaired CD4(+) T cell migration to the skin in mouse models of DOCK8 deficiency

DOCK8 deficiency in humans and mice leads to multiple defects in immune cell numbers and function. Patients with this immunodeficiency have a high morbidity and mortality, and are distinguished by chronic, cutaneous viral infections, including those caused by herpes simplex virus (HSV). The underlyi...

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Vydáno v:Immunol Cell Biol
Hlavní autoři: Flesch, Inge EA, Randall, Katrina L, Hollett, Natasha A, Law, HseiDi, Miosge, Lisa A, Sontani, Yovina, Goodnow, Christopher C, Tscharke, David C
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496291/
https://ncbi.nlm.nih.gov/pubmed/25776845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2015.32
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