Loss of endocytosis-associated RabGEF1 causes aberrant morphogenesis and altered autophagy in photoreceptors leading to retinal degeneration

Rab-GTPases and associated effectors mediate cargo transport through the endomembrane system of eukaryotic cells, regulating key processes such as membrane turnover, signal transduction, protein recycling and degradation. Using developmental transcriptome data, we identified Rabgef1 (encoding the pr...

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Vydáno v:PLoS Genet
Hlavní autoři: Hargrove-Grimes, Passley, Mondal, Anupam K., Gumerson, Jessica, Nellissery, Jacob, Aponte, Angel M., Gieser, Linn, Qian, Haohua, Fariss, Robert N., Bonifacino, Juan S., Li, Tiansen, Swaroop, Anand
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790415/
https://ncbi.nlm.nih.gov/pubmed/33362196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009259
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