The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells

Tumor hypoxia and the hypoxia inducible factor-1, HIF-1, play critical roles in cancer progression and metastasis. We previously showed that hypoxia activates the endosomal GTPase Rab5, leading to tumor cell migration and invasion, and that these events do not involve changes in Rab protein expressi...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Rivas, Solange, Silva, Patricio, Reyes, Montserrat, Sepúlveda, Hugo, Solano, Luis, Acuña, Juan, Guerrero, Marisol, Varas-Godoy, Manuel, Quest, Andrew F. G., Montecino, Martín, Torres, Vicente A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749157/
https://ncbi.nlm.nih.gov/pubmed/33339852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79270-6
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