Thymic Stromal Lymphopoietin Contributes to Myeloid Hyperplasia and Increased Immunoglobulins, But Not Epidermal Hyperplasia, in RabGEF1-Deficient Mice

Mice overexpressing the proallergic cytokine thymic stromal lymphopoietin (TSLP) in the skin develop a pathology resembling atopic dermatitis. RabGEF1, a guanine nucleotide exchange factor for Rab5 GTPase, is a negative regulator of IgE-dependent mast cell activation, and Rabgef1(−/−) and TSLP trans...

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Bibliografiske detaljer
Main Authors: Tsai, Mindy, Chen, Ching-Cheng, Mukai, Kaori, Song, Chang Ho, Thompson, Lucas J., Ziegler, Steven F., Tam, See-Ying, Galli, Stephen J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2010
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966799/
https://ncbi.nlm.nih.gov/pubmed/20829437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.100181
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