Loss of endocytosis-associated RabGEF1 causes aberrant morphogenesis and altered autophagy in photoreceptors leading to retinal degeneration

Rab-GTPases and associated effectors mediate cargo transport through the endomembrane system of eukaryotic cells, regulating key processes such as membrane turnover, signal transduction, protein recycling and degradation. Using developmental transcriptome data, we identified Rabgef1 (encoding the pr...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Hargrove-Grimes, Passley, Mondal, Anupam K., Gumerson, Jessica, Nellissery, Jacob, Aponte, Angel M., Gieser, Linn, Qian, Haohua, Fariss, Robert N., Bonifacino, Juan S., Li, Tiansen, Swaroop, Anand
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790415/
https://ncbi.nlm.nih.gov/pubmed/33362196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009259
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