Ribociclib mitigates cisplatin-associated kidney injury through retinoblastoma-1 dependent mechanisms

Aberrant cell cycle activation is a hallmark of carcinogenesis. Recently three cell cycle targeting cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have been approved for the treatment of metastatic breast cancer. CDK4/6 inhibitors suppress proliferation through inhibition of CDK4/6-dependent retino...

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Bibliografiske detaljer
Udgivet i:Biochem Pharmacol
Main Authors: Kim, Ji Young, Jayne, Laura A., Bai, Yuntao, Feng, Mei Ji He Ho, Clark, Matthew A., Chung, Sangwoon, Christman, John W., Cianciolo, Rachel E., Pabla, Navjot Singh
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7789910/
https://ncbi.nlm.nih.gov/pubmed/32229099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2020.113939
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