A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury

Renal tubular epithelial cells (RTECs) perform the essential function of maintaining the constancy of body fluid composition and volume. Toxic, inflammatory, or hypoxic-insults to RTECs can cause systemic fluid imbalance, electrolyte abnormalities and metabolic waste accumulation- manifesting as acu...

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Udgivet i:Nat Commun
Main Authors: Kim, Ji Young, Bai, Yuntao, Jayne, Laura A., Hector, Ralph D., Persaud, Avinash K., Ong, Su Sien, Rojesh, Shreshtha, Raj, Radhika, Feng, Mei Ji He Ho, Chung, Sangwoon, Cianciolo, Rachel E., Christman, John W., Campbell, Moray J., Gardner, David S., Baker, Sharyn D., Sparreboom, Alex, Govindarajan, Rajgopal, Singh, Harpreet, Chen, Taosheng, Poi, Ming, Susztak, Katalin, Cobb, Stuart R., Pabla, Navjot Singh
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174303/
https://ncbi.nlm.nih.gov/pubmed/32317630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15638-6
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