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Rad18 mediates specific mutational signatures and shapes the genomic landscape of carcinogen-induced tumors in vivo
The E3 ubiquitin ligase Rad18 promotes a damage-tolerant and error-prone mode of DNA replication termed trans-lesion synthesis that is pathologically activated in cancer. However, the impact of vertebrate Rad18 on cancer genomes is not known. To determine how Rad18 affects mutagenesis in vivo, we ha...
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| Publicat a: | NAR Cancer |
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| Autors principals: | , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7787264/ https://ncbi.nlm.nih.gov/pubmed/33447826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa037 |
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