Rad18 mediates specific mutational signatures and shapes the genomic landscape of carcinogen-induced tumors in vivo

The E3 ubiquitin ligase Rad18 promotes a damage-tolerant and error-prone mode of DNA replication termed trans-lesion synthesis that is pathologically activated in cancer. However, the impact of vertebrate Rad18 on cancer genomes is not known. To determine how Rad18 affects mutagenesis in vivo, we ha...

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Bibliographic Details
Published in:NAR Cancer
Main Authors: Lou, Jitong, Yang, Yang, Gu, Qisheng, Price, Brandon A, Qiu, Yuheng, Fedoriw, Yuri, Desai, Siddhi, Mose, Lisle E, Chen, Brian, Tateishi, Satoshi, Parker, Joel S, Vaziri, Cyrus, Wu, Di
Format: Artigo
Language:Inglês
Published: Oxford University Press 2021
Subjects:
Cancer Genomics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7787264/
https://ncbi.nlm.nih.gov/pubmed/33447826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa037
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