Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo

In cultured cancer cells the E3 ubiquitin ligase Rad18 activates Trans-Lesion Synthesis (TLS) and the Fanconi Anemia (FA) pathway. However, physiological roles of Rad18 in DNA damage tolerance and carcinogenesis are unknown and were investigated here. Primary hematopoietic stem and progenitor cells...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Yang, Yang, Poe, Jonathan C., Yang, Lisong, Fedoriw, Andrew, Desai, Siddhi, Magnuson, Terry, Li, Zhiguo, Fedoriw, Yuri, Araki, Kimi, Gao, Yanzhe, Tateishi, Satoshi, Sarantopoulos, Stefanie, Vaziri, Cyrus
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872084/
https://ncbi.nlm.nih.gov/pubmed/26883629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw072
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