Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo

In cultured cancer cells the E3 ubiquitin ligase Rad18 activates Trans-Lesion Synthesis (TLS) and the Fanconi Anemia (FA) pathway. However, physiological roles of Rad18 in DNA damage tolerance and carcinogenesis are unknown and were investigated here. Primary hematopoietic stem and progenitor cells...

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書目詳細資料
發表在:Nucleic Acids Res
Main Authors: Yang, Yang, Poe, Jonathan C., Yang, Lisong, Fedoriw, Andrew, Desai, Siddhi, Magnuson, Terry, Li, Zhiguo, Fedoriw, Yuri, Araki, Kimi, Gao, Yanzhe, Tateishi, Satoshi, Sarantopoulos, Stefanie, Vaziri, Cyrus
格式: Artigo
語言:Inglês
出版: Oxford University Press 2016
主題:
Genome Integrity, Repair and Replication
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872084/
https://ncbi.nlm.nih.gov/pubmed/26883629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw072
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