Diverse roles of RAD18 and Y-family DNA polymerases in tumorigenesis

Mutagenesis is a hallmark and enabling characteristic of cancer cells. The E3 ubiquitin ligase RAD18 and its downstream effectors, the ‘Y-family’ Trans-Lesion Synthesis (TLS) DNA polymerases, confer DNA damage tolerance at the expense of DNA replication fidelity. Thus, RAD18 and TLS polymerases are...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Yang, Yang, Gao, Yanzhe, Zlatanou, Anastasia, Tateishi, Satoshi, Yurchenko, Vyacheslav, Rogozin, Igor B., Vaziri, Cyrus
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056224/
https://ncbi.nlm.nih.gov/pubmed/29683380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1456296
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