HDAC4 and HDAC5 form a complex with DREAM that epigenetically down-regulates NCX3 gene and its pharmacological inhibition reduces neuronal stroke damage

The histone deacetylases (HDACs)-dependent mechanisms regulating gene transcription of the Na(+)/Ca(+) exchanger isoform 3 (ncx3) after stroke are still unknown. Overexpression or knocking-down of HDAC4/HDAC5 down-regulates or increases, respectively, NCX3 mRNA and protein. Likewise, MC1568 (class I...

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Publicado en:J Cereb Blood Flow Metab
Autores principales: Formisano, Luigi, Laudati, Giusy, Guida, Natascia, Mascolo, Luigi, Serani, Angelo, Cuomo, Ornella, Cantile, Maria, Boscia, Francesca, Molinaro, Pasquale, Anzilotti, Serenella, Pizzorusso, Vincenzo, Di Renzo, Gianfranco, Pignataro, Giuseppe, Annunziato, Lucio
Formato: Artigo
Lenguaje:Inglês
Publicado: SAGE Publications 2019
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7786841/
https://ncbi.nlm.nih.gov/pubmed/31696766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X19884742
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