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HDAC4 and HDAC5 form a complex with DREAM that epigenetically down-regulates NCX3 gene and its pharmacological inhibition reduces neuronal stroke damage
The histone deacetylases (HDACs)-dependent mechanisms regulating gene transcription of the Na(+)/Ca(+) exchanger isoform 3 (ncx3) after stroke are still unknown. Overexpression or knocking-down of HDAC4/HDAC5 down-regulates or increases, respectively, NCX3 mRNA and protein. Likewise, MC1568 (class I...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Cereb Blood Flow Metab |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
SAGE Publications
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7786841/ https://ncbi.nlm.nih.gov/pubmed/31696766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X19884742 |
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