Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism

The Na(+)-Ca(2+) exchanger 1 (NCX1) is reduced in stroke by the RE1-silencing transcription factor (REST), whereas it is increased in ischemic brain preconditioning (PC) by hypoxia-inducible factor 1 (HIF-1). Because ncx1 brain promoter (ncx1-Br) has five putative consensus sequences, named Sp1A–E,...

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Publicat a:J Neurosci
Autors principals: Formisano, Luigi, Guida, Natascia, Valsecchi, Valeria, Cantile, Maria, Cuomo, Ornella, Vinciguerra, Antonio, Laudati, Giusy, Pignataro, Giuseppe, Sirabella, Rossana, Di Renzo, Gianfranco, Annunziato, Lucio
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705442/
https://ncbi.nlm.nih.gov/pubmed/25972164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2174-14.2015
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