Heparan sulfate synthesized by Ext1 regulates receptor tyrosine kinase signaling and promotes resistance to EGFR inhibitors in GBM

Signaling from multiple receptor tyrosine kinases (RTKs) contributes to therapeutic resistance in glioblastoma (GBM). Heparan sulfate (HS), present on cell surfaces and in the extracellular matrix, regulates cell signaling via several mechanisms. To investigate the role for HS in promoting RTK signa...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Mol Cancer Res
Autori principali: Ohkawa, Yuki, Wade, Anna, Lindberg, Olle R., Chen, Katharine Y., Tran, Vy M., Brown, Spencer J., Kumar, Anupam, Kalita, Mausam, James, C. David, Phillips, Joanna J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785678/
https://ncbi.nlm.nih.gov/pubmed/33028660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-20-0420
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi