Modulation of arousal and sleep/wake architecture by M(1) PAM VU0453595 across young and aged rodents and nonhuman primates

Degeneration of basal forebrain cholinergic circuitry represents an early event in the development of Alzheimer’s disease (AD). These alterations in central cholinergic function are associated with disruptions in arousal, sleep/wake architecture, and cognition. Changes in sleep/wake architecture are...

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Publicat a:Neuropsychopharmacology
Autors principals: Gould, Robert W., Russell, Jason K., Nedelcovych, Michael T., Bubser, Michael, Blobaum, Anna L., Bridges, Thomas M., Newhouse, Paul A., Lindsley, Craig W., Conn, P. Jeffrey, Nader, Michael A., Jones, Carrie K.
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7784923/
https://ncbi.nlm.nih.gov/pubmed/32868847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-020-00812-7
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