Double somatic mismatch repair gene pathogenic variants as common as Lynch syndrome among endometrial cancer patients

OBJECTIVE. Lynch syndrome is the most common cause of inherited endometrial cancer, attributable to germline pathogenic variants (PV) in mismatch repair (MMR) genes. Tumor microsatellite instability (MSI-high) and MMR IHC abnormalities are characteristics of Lynch syndrome. Double somatic MMR gene P...

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Enregistré dans:
Détails bibliographiques
Publié dans:Gynecol Oncol
Auteurs principaux: Hampel, Heather, Pearlman, Rachel, de la Chapelle, Albert, Pritchard, Colin C., Zhao, Weiqiang, Jones, Dan, Yilmaz, Ahmet, Chen, Wei, Frankel, Wendy L., Suarez, Adrian A., Cosgrove, Casey, Backes, Floor, Copeland, Larry, Fowler, Jeffrey, O'Malley, David, Salani, Ritu, McElroy, Joseph P., Stanich, Peter P., Goodfellow, Paul, Cohn, David E.
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7783191/
https://ncbi.nlm.nih.gov/pubmed/33393477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2020.10.012
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