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Double somatic mismatch repair gene pathogenic variants as common as Lynch syndrome among endometrial cancer patients
OBJECTIVE. Lynch syndrome is the most common cause of inherited endometrial cancer, attributable to germline pathogenic variants (PV) in mismatch repair (MMR) genes. Tumor microsatellite instability (MSI-high) and MMR IHC abnormalities are characteristics of Lynch syndrome. Double somatic MMR gene P...
Shranjeno v:
| izdano v: | Gynecol Oncol |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7783191/ https://ncbi.nlm.nih.gov/pubmed/33393477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2020.10.012 |
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