Double somatic mismatch repair gene pathogenic variants as common as Lynch syndrome among endometrial cancer patients

OBJECTIVE. Lynch syndrome is the most common cause of inherited endometrial cancer, attributable to germline pathogenic variants (PV) in mismatch repair (MMR) genes. Tumor microsatellite instability (MSI-high) and MMR IHC abnormalities are characteristics of Lynch syndrome. Double somatic MMR gene P...

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Publicado no:Gynecol Oncol
Main Authors: Hampel, Heather, Pearlman, Rachel, de la Chapelle, Albert, Pritchard, Colin C., Zhao, Weiqiang, Jones, Dan, Yilmaz, Ahmet, Chen, Wei, Frankel, Wendy L., Suarez, Adrian A., Cosgrove, Casey, Backes, Floor, Copeland, Larry, Fowler, Jeffrey, O'Malley, David, Salani, Ritu, McElroy, Joseph P., Stanich, Peter P., Goodfellow, Paul, Cohn, David E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7783191/
https://ncbi.nlm.nih.gov/pubmed/33393477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2020.10.012
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