Epigenetic silencing of MLH1 in endometrial cancers is associated with larger tumor volume, increased rate of lymph node positivity and reduced recurrence-free survival

OBJECTIVES: To determine the relationship between mismatch repair (MMR) classification and clinicopathologic features including tumor volume, and explore outcomes by MMR class in a contemporary cohort. METHODS: Single institution cohort evaluating MMR classification for endometrial cancers (EC). MMR...

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Detalhes bibliográficos
Publicado no:Gynecol Oncol
Main Authors: Cosgrove, Casey M, Cohn, David E, Hampel, Heather, Frankel, Wendy L, Jones, Dan, McElroy, Joseph P, Suarez, Adrian A, Zhao, Weiqiang, Chen, Wei, Salani, Ritu, Copeland, Larry J, O’Malley, David M, Fowler, Jeffrey M, Yilmaz, Ahmet, Chassen, Alexis S, Pearlman, Rachel, Goodfellow, Paul J, Backes, Floor J
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601318/
https://ncbi.nlm.nih.gov/pubmed/28709704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2017.07.003
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