Clinical Characteristics of Colorectal Cancer Patients with Double Somatic Mismatch Repair Mutations Compared to Lynch Syndrome

BACKGROUND: Colorectal cancer (CRC) patients with mismatch repair-deficient (dMMR) tumors without MLH1 methylation or germline MMR pathogenic variants (PVs) were previously thought to have Lynch syndrome (LS). It’s now appreciated that they can have double somatic (DS) MMR PVs. We explored clinical...

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Veröffentlicht in:J Med Genet
Hauptverfasser: Pearlman, Rachel, Haraldsdottir, Sigurdis, de la Chapelle, Albert, Jonasson, Jon G., Liyanarachchi, Sandya, Frankel, Wendy L., Rafnar, Thorunn, Stefansson, Kari, Pritchard, Colin C., Hampel, Heather
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748629/
https://ncbi.nlm.nih.gov/pubmed/30877237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmedgenet-2018-105698
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