Colon and Endometrial Cancers with Mismatch Repair Deficiency can Arise from Somatic, Rather Than Germline, Mutations

BACKGROUND & AIMS: Patients with Lynch syndrome carry germline mutations in single alleles of genes encoding the MMR proteins MLH1, MSH2, MSH6 and PMS2; when the second allele becomes mutated, cancer can develop. Increased screening for Lynch syndrome has identified patients with tumors that hav...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Haraldsdottir, Sigurdis, Hampel, Heather, Tomsic, Jerneja, Frankel, Wendy L., Pearlman, Rachel, de la Chapelle, Albert, Pritchard, Colin C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294551/
https://ncbi.nlm.nih.gov/pubmed/25194673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.08.041
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