Frequent PIK3CA Mutations in Colorectal and Endometrial Cancer with Double Somatic Mismatch Repair Mutations

BACKGROUND & AIMS: Double somatic mutations in mismatch repair (MMR) genes have recently been described in colorectal and endometrial cancers with microsatellite instability (MSI) not attributable to MLH1 hypermethylation or germline mutation. We sought to define the molecular phenotype of this...

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Pubblicato in:Gastroenterology
Autori principali: Cohen, Stacey A., Turner, Emily H., Beightol, Mallory B., Jacobson, Angela, Gooley, Ted A., Salipante, Stephen J., Haraldsdottir, Sigurdis, Smith, Christina, Scroggins, Sheena, Tait, Jonathan F., Grady, William M., Lin, Edward H., Cohn, David E., Goodfellow, Paul J., Arnold, Mark W., de la Chapelle, Albert, Pearlman, Rachel, Hampel, Heather, Pritchard, Colin C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016834/
https://ncbi.nlm.nih.gov/pubmed/27302833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2016.06.004
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