Cyclophosphamide Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcγR Expression

Therapy-resistant microenvironments represent a major barrier toward effective elimination of disseminated cancer. Many hematologic and solid tumors are resistant to therapeutic antibodies in the bone marrow (BM), but not in the periphery (e.g., spleen). We previously showed that cyclophosphamide (C...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Roghanian, Ali, Hu, Guangan, Fraser, Christopher, Singh, Maneesh, Foxall, Russell B., Meyer, Matthew J., Lees, Emma, Huet, Heather, Glennie, Martin J., Beers, Stephen A., Lim, Sean H., Ashton-Key, Margaret, Thirdborough, Stephen M., Cragg, Mark S., Chen, Jianzhu
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7780711/
https://ncbi.nlm.nih.gov/pubmed/31451483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0835
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