Cyclophosphamide Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcγR Expression

Therapy-resistant microenvironments represent a major barrier toward effective elimination of disseminated cancer. Many hematologic and solid tumors are resistant to therapeutic antibodies in the bone marrow (BM), but not in the periphery (e.g., spleen). We previously showed that cyclophosphamide (C...

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Udgivet i:Cancer Immunol Res
Main Authors: Roghanian, Ali, Hu, Guangan, Fraser, Christopher, Singh, Maneesh, Foxall, Russell B., Meyer, Matthew J., Lees, Emma, Huet, Heather, Glennie, Martin J., Beers, Stephen A., Lim, Sean H., Ashton-Key, Margaret, Thirdborough, Stephen M., Cragg, Mark S., Chen, Jianzhu
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7780711/
https://ncbi.nlm.nih.gov/pubmed/31451483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0835
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