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Fc-Engineering for Modulated Effector Functions—Improving Antibodies for Cancer Treatment

The majority of monoclonal antibody (mAb) therapeutics possess the ability to engage innate immune effectors through interactions mediated by their fragment crystallizable (Fc) domain. By delivering Fc-Fc gamma receptor (FcγR) and Fc-C1q interactions, mAb are able to link exquisite specificity to po...

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Detalhes bibliográficos
Publicado no:Antibodies (Basel)
Main Authors: Liu, Rena, Oldham, Robert J., Teal, Emma, Beers, Stephen A., Cragg, Mark S.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709126/
https://ncbi.nlm.nih.gov/pubmed/33212886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib9040064
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