Fc-Engineering for Modulated Effector Functions—Improving Antibodies for Cancer Treatment

The majority of monoclonal antibody (mAb) therapeutics possess the ability to engage innate immune effectors through interactions mediated by their fragment crystallizable (Fc) domain. By delivering Fc-Fc gamma receptor (FcγR) and Fc-C1q interactions, mAb are able to link exquisite specificity to po...

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Bibliographic Details
Published in:Antibodies (Basel)
Main Authors: Liu, Rena, Oldham, Robert J., Teal, Emma, Beers, Stephen A., Cragg, Mark S.
Format: Artigo
Language:Inglês
Published: MDPI 2020
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709126/
https://ncbi.nlm.nih.gov/pubmed/33212886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib9040064
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