Engineered antibody Fc variants with enhanced effector function

Antibody-dependent cell-mediated cytotoxicity, a key effector function for the clinical efficacy of monoclonal antibodies, is mediated primarily through a set of closely related Fcγ receptors with both activating and inhibitory activities. By using computational design algorithms and high-throughput...

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Detalhes bibliográficos
Main Authors: Lazar, Greg A., Dang, Wei, Karki, Sher, Vafa, Omid, Peng, Judy S., Hyun, Linus, Chan, Cheryl, Chung, Helen S., Eivazi, Araz, Yoder, Sean C., Vielmetter, Jost, Carmichael, David F., Hayes, Robert J., Dahiyat, Bassil I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1389705/
https://ncbi.nlm.nih.gov/pubmed/16537476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508123103
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