Engineered antibody Fc variants with enhanced effector function

Antibody-dependent cell-mediated cytotoxicity, a key effector function for the clinical efficacy of monoclonal antibodies, is mediated primarily through a set of closely related Fcγ receptors with both activating and inhibitory activities. By using computational design algorithms and high-throughput...

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Main Authors: Lazar, Greg A., Dang, Wei, Karki, Sher, Vafa, Omid, Peng, Judy S., Hyun, Linus, Chan, Cheryl, Chung, Helen S., Eivazi, Araz, Yoder, Sean C., Vielmetter, Jost, Carmichael, David F., Hayes, Robert J., Dahiyat, Bassil I.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2006
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1389705/
https://ncbi.nlm.nih.gov/pubmed/16537476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508123103
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