Učitavanje...
A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens
Bispecific antibodies based on full-length antibody structures are more optimal than fragment-based formats because they benefit from the favorable properties of the Fc region. However, the homodimeric nature of Fc effectively imposes bivalent binding on all current full-length bispecific antibodies...
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| Glavni autori: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Landes Bioscience
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3242841/ https://ncbi.nlm.nih.gov/pubmed/22123055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.6.18123 |
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