A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens

Bispecific antibodies based on full-length antibody structures are more optimal than fragment-based formats because they benefit from the favorable properties of the Fc region. However, the homodimeric nature of Fc effectively imposes bivalent binding on all current full-length bispecific antibodies...

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Autori principali: Moore, Gregory L, Bautista, Cristina, Pong, Erik, Nguyen, Duc-Hanh T, Jacinto, Jonathan, Eivazi, Araz, Muchhal, Umesh S, Karki, Sher, Chu, Seung Y, Lazar, Greg A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242841/
https://ncbi.nlm.nih.gov/pubmed/22123055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.6.18123
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