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Engineered antibody Fc variants with enhanced effector function
Antibody-dependent cell-mediated cytotoxicity, a key effector function for the clinical efficacy of monoclonal antibodies, is mediated primarily through a set of closely related Fcγ receptors with both activating and inhibitory activities. By using computational design algorithms and high-throughput...
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| Główni autorzy: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2006
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1389705/ https://ncbi.nlm.nih.gov/pubmed/16537476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508123103 |
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