Activatory and Inhibitory Fcγ Receptors Augment Rituximab-mediated Internalization of CD20 Independent of Signaling via the Cytoplasmic Domain

Type I anti-CD20 mAb such as rituximab and ofatumumab engage with the inhibitory FcγR, FcγRIIb on the surface of B cells, resulting in immunoreceptor tyrosine-based inhibitory motif (ITIM) phosphorylation. Internalization of the CD20·mAb·FcγRIIb complex follows, the rate of which correlates with Fcγ...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Vaughan, Andrew T., Chan, Claude H. T., Klein, Christian, Glennie, Martin J., Beers, Stephen A., Cragg, Mark S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342459/
https://ncbi.nlm.nih.gov/pubmed/25568316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.593806
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