Identification of a New Heterocyclic Scaffold for Inhibitors of the Polo-Box Domain of Polo-like Kinase 1

As a mitotic-specific target widely deregulated in various human cancers, polo-like kinase 1 (Plk1) has been extensively explored for anticancer activity and drug discovery. Although multiple catalytic domain inhibitors were tested in preclinical and clinical studies, their efficacies are limited by...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Med Chem
Main Authors: Alverez, Celeste N., Park, Jung-Eun, Toti, Kiran S., Xia, Yangliu, Krausz, Kristopher W., Rai, Ganesha, Bang, Jeong K., Gonzalez, Frank J., Jacobson, Kenneth A., Lee, Kyung S.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769008/
https://ncbi.nlm.nih.gov/pubmed/33175530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01669
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker