Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1

The polo-box domain (PBD) of polo-like kinase 1 (Plk1) is essentially required for the function of Plk1 in cell proliferation. The availability of the phosphopeptide-binding pocket on PBD provides a unique opportunity to develop novel protein–protein interaction inhibitors. Recent identification of...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Murugan, Ravichandran N., Park, Jung-Eun, Lim, Dan, Ahn, Mija, Cheong, Chaejoon, Kwon, Taeho, Nam, Ky-Youb, Choi, Sun Ho, Kim, Bo Yeon, Yoon, Do-Young, Yaffe, Michael B., Yu, Dae-Yeul, Lee, Kyung S., Bang, Jeong Kyu
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7561269/
https://ncbi.nlm.nih.gov/pubmed/23498919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.02.020
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