Exploring the Binding Nature of Pyrrolidine Pocket-Dependent Interactions in the Polo-Box Domain of Polo-Like Kinase 1

BACKGROUND: Over the years, a great deal of effort has been focused on the design and synthesis of potent, linear peptide inhibitors targeting the polo-like kinase 1 (Plk1), which is critically involved in multiple mitotic processes and has been established as an adverse prognostic marker for tumor...

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Detalhes bibliográficos
Main Authors: Murugan, Ravichandran N., Ahn, Mija, Lee, Woo Cheol, Kim, Hye-Yeon, Song, Jung Hyun, Cheong, Chaejoon, Hwang, Eunha, Seo, Ji-Hyung, Shin, Song Yub, Choi, Sun Ho, Park, Jung-Eun, Bang, Jeong Kyu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819306/
https://ncbi.nlm.nih.gov/pubmed/24223211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080043
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