Design and Synthesis of a Cell-Permeable, Drug-Like Small Molecule Inhibitor Targeting the Polo-Box Domain of Polo-Like Kinase 1

BACKGROUND: Polo-like kinase-1 (Plk1) plays a crucial role in cell proliferation and the inhibition of Plk1 has been considered as a potential target for specific inhibitory drugs in anti-cancer therapy. Several research groups have identified peptide-based inhibitors that target the polo-box domain...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Srinivasrao, Ganipisetti, Park, Jung-Eun, Kim, Sungmin, Ahn, Mija, Cheong, Chaejoon, Nam, Ky-Youb, Gunasekaran, Pethaiah, Hwang, Eunha, Kim, Nam-Hyung, Shin, Song Yub, Lee, Kyung S., Ryu, Eunkyung, Bang, Jeong Kyu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161390/
https://ncbi.nlm.nih.gov/pubmed/25211362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107432
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg