Design and Synthesis of a Cell-Permeable, Drug-Like Small Molecule Inhibitor Targeting the Polo-Box Domain of Polo-Like Kinase 1

BACKGROUND: Polo-like kinase-1 (Plk1) plays a crucial role in cell proliferation and the inhibition of Plk1 has been considered as a potential target for specific inhibitory drugs in anti-cancer therapy. Several research groups have identified peptide-based inhibitors that target the polo-box domain...

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Main Authors: Srinivasrao, Ganipisetti, Park, Jung-Eun, Kim, Sungmin, Ahn, Mija, Cheong, Chaejoon, Nam, Ky-Youb, Gunasekaran, Pethaiah, Hwang, Eunha, Kim, Nam-Hyung, Shin, Song Yub, Lee, Kyung S., Ryu, Eunkyung, Bang, Jeong Kyu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161390/
https://ncbi.nlm.nih.gov/pubmed/25211362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107432
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