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Probing Binding Modes of Small Molecule Inhibitors to the Polo-Box Domain of Human Polo-like Kinase 1

[Image: see text] Purpurogallin (PPG, 2) and poloxin (3) have been reported as inhibitors of the polo-box domain (PBD) of human polo-like kinase 1. However, our experimental results demonstrated that PPG, but not poloxin, binds to the phospho-binding pocket of the PBD, suggesting that their modes of...

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Autors principals: Liao, Chenzhong, Park, Jung-Eun, Bang, Jeong K., Nicklaus, Marc C., Lee, Kyung S.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2010
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898210/
https://ncbi.nlm.nih.gov/pubmed/20625469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100020e
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