Multicomponent synthesis, binding mode and structure-activity relationships of selective histone deacetylase 6 (HDAC6) inhibitors with bifurcated capping groups

The histone deacetylase 6 (HDAC6) is an emerging target for the treatment of cancer, neurodegenerative diseases, inflammation, and other diseases. Here, we present the multicomponent synthesis and structure-activity relationships of a series of tetrazole-based HDAC6 inhibitors. We discovered the hit...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Reßing, Nina, Sönnichsen, Melf, Osko, Jeremy D., Schöler, Andrea, Schliehe-Diecks, Julian, Skerhut, Alexander, Borkhardt, Arndt, Hauer, Julia, Kassack, Matthias U., Christianson, David. W., Bhatia, Sanil, Hansen, Finn K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762828/
https://ncbi.nlm.nih.gov/pubmed/32803970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01888
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