One Step Closer to Clinical Translation: Enhanced Tumor Targeting of [(99m)Tc]Tc-DB4 and [(111)In]In-SG4 in Mice Treated with Entresto

Background: Peptide radioligands may serve as radionuclide carriers to tumor sites overexpressing their cognate receptor for diagnostic or therapeutic purposes. Treatment of mice with the neprilysin (NEP)-inhibitor phosphoramidon was previously shown to improve the metabolic stability and tumor upta...

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Vydáno v:Pharmaceutics
Hlavní autoři: Kanellopoulos, Panagiotis, Kaloudi, Aikaterini, Rouchota, Maritina, Loudos, George, de Jong, Marion, Krenning, Eric P., Nock, Berthold A., Maina, Theodosia
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7760338/
https://ncbi.nlm.nih.gov/pubmed/33256013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12121145
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