Comparing Gly(11)/dAla(11)-Replacement vs. the in-Situ Neprilysin-Inhibition Approach on the Tumor-targeting Efficacy of the (111)In-SB3/(111)In-SB4 Radiotracer Pair

Background: The GRPR-antagonist (68)Ga-SB3 visualized prostate cancer lesions in animal models and in patients. Switching radiometal from (68)Ga to (111)In impaired tumor targeting in mice, but coinjection of the neprilysin (NEP)-inhibitor phosphoramidon (PA) stabilized (111)In-SB3 in circulation an...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Lymperis, Emmanouil, Kaloudi, Aikaterini, Kanellopoulos, Panagiotis, de Jong, Marion, Krenning, Eric P., Nock, Berthold A., Maina, Theodosia
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6471467/
https://ncbi.nlm.nih.gov/pubmed/30871262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24061015
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