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Comparing Gly(11)/dAla(11)-Replacement vs. the in-Situ Neprilysin-Inhibition Approach on the Tumor-targeting Efficacy of the (111)In-SB3/(111)In-SB4 Radiotracer Pair
Background: The GRPR-antagonist (68)Ga-SB3 visualized prostate cancer lesions in animal models and in patients. Switching radiometal from (68)Ga to (111)In impaired tumor targeting in mice, but coinjection of the neprilysin (NEP)-inhibitor phosphoramidon (PA) stabilized (111)In-SB3 in circulation an...
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| Gepubliceerd in: | Molecules |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
MDPI
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6471467/ https://ncbi.nlm.nih.gov/pubmed/30871262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24061015 |
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