Beyond the Influence of IDH Mutations: Exploring Epigenetic Vulnerabilities in Chondrosarcoma

SIMPLE SUMMARY: Cartilage tumors frequently harbor mutations in the isocitrate dehydrogenase (IDH1 or IDH2) genes. These mutations cause an increase in the levels of the oncometabolite D-2-hydroxyglutarate (D-2-HG), which leads to widespread changes in several cellular processes, including the epige...

詳細記述

保存先:
書誌詳細
出版年:Cancers (Basel)
主要な著者: Venneker, Sanne, Kruisselbrink, Alwine B., Baranski, Zuzanna, Palubeckaite, Ieva, Briaire-de Bruijn, Inge H., Oosting, Jan, French, Pim J., Danen, Erik H. J., Bovée, Judith V. M. G.
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7760027/
https://ncbi.nlm.nih.gov/pubmed/33266275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12123589
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