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Beyond the Influence of IDH Mutations: Exploring Epigenetic Vulnerabilities in Chondrosarcoma
SIMPLE SUMMARY: Cartilage tumors frequently harbor mutations in the isocitrate dehydrogenase (IDH1 or IDH2) genes. These mutations cause an increase in the levels of the oncometabolite D-2-hydroxyglutarate (D-2-HG), which leads to widespread changes in several cellular processes, including the epige...
में बचाया:
| में प्रकाशित: | Cancers (Basel) |
|---|---|
| मुख्य लेखकों: | , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
MDPI
2020
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7760027/ https://ncbi.nlm.nih.gov/pubmed/33266275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12123589 |
| टैग : |
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