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Beyond the Influence of IDH Mutations: Exploring Epigenetic Vulnerabilities in Chondrosarcoma

SIMPLE SUMMARY: Cartilage tumors frequently harbor mutations in the isocitrate dehydrogenase (IDH1 or IDH2) genes. These mutations cause an increase in the levels of the oncometabolite D-2-hydroxyglutarate (D-2-HG), which leads to widespread changes in several cellular processes, including the epige...

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Bibliografske podrobnosti
izdano v:	Cancers (Basel)
Main Authors:	Venneker, Sanne, Kruisselbrink, Alwine B., Baranski, Zuzanna, Palubeckaite, Ieva, Briaire-de Bruijn, Inge H., Oosting, Jan, French, Pim J., Danen, Erik H. J., Bovée, Judith V. M. G.
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI 2020
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7760027/ https://ncbi.nlm.nih.gov/pubmed/33266275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12123589
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Beyond the Influence of IDH Mutations: Exploring Epigenetic Vulnerabilities in Chondrosarcoma

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