Targeting the NAD Salvage Synthesis Pathway as a Novel Therapeutic Strategy for Osteosarcomas with Low NAPRT Expression

For osteosarcoma (OS), the most common primary malignant bone tumor, overall survival has hardly improved over the last four decades. Especially for metastatic OS, novel therapeutic targets are urgently needed. A hallmark of cancer is aberrant metabolism, which justifies targeting metabolic pathways...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Mol Sci
Prif Awduron: Franceschini, Natasja, Oosting, Jan, Tamsma, Maud, Niessen, Bertine, Bruijn, Inge Briaire-de, van den Akker, Brendy, Kruisselbrink, Alwine B., Palubeckaitė, Ieva, Bovée, Judith V. M. G., Cleton-Jansen, Anne-Marie
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8230647/
https://ncbi.nlm.nih.gov/pubmed/34200964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22126273
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