Targeting the NAD Salvage Synthesis Pathway as a Novel Therapeutic Strategy for Osteosarcomas with Low NAPRT Expression

For osteosarcoma (OS), the most common primary malignant bone tumor, overall survival has hardly improved over the last four decades. Especially for metastatic OS, novel therapeutic targets are urgently needed. A hallmark of cancer is aberrant metabolism, which justifies targeting metabolic pathways...

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Pubblicato in:Int J Mol Sci
Autori principali: Franceschini, Natasja, Oosting, Jan, Tamsma, Maud, Niessen, Bertine, Bruijn, Inge Briaire-de, van den Akker, Brendy, Kruisselbrink, Alwine B., Palubeckaitė, Ieva, Bovée, Judith V. M. G., Cleton-Jansen, Anne-Marie
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8230647/
https://ncbi.nlm.nih.gov/pubmed/34200964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22126273
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