Targeting the NAD Salvage Synthesis Pathway as a Novel Therapeutic Strategy for Osteosarcomas with Low NAPRT Expression

For osteosarcoma (OS), the most common primary malignant bone tumor, overall survival has hardly improved over the last four decades. Especially for metastatic OS, novel therapeutic targets are urgently needed. A hallmark of cancer is aberrant metabolism, which justifies targeting metabolic pathways...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Franceschini, Natasja, Oosting, Jan, Tamsma, Maud, Niessen, Bertine, Bruijn, Inge Briaire-de, van den Akker, Brendy, Kruisselbrink, Alwine B., Palubeckaitė, Ieva, Bovée, Judith V. M. G., Cleton-Jansen, Anne-Marie
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8230647/
https://ncbi.nlm.nih.gov/pubmed/34200964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22126273
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