Targeting glutaminolysis in chondrosarcoma in context of the IDH1/2 mutation

INTRODUCTION: Chondrosarcoma is a malignant cartilage-forming bone tumour in which mutations in IDH1 and IDH2 frequently occur. Previous studies suggest an increased dependency on glutaminolysis in IDH1/2 mutant cells, which resulted in clinical trials with the drugs CB-839, metformin and chloroquin...

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Gepubliceerd in:Br J Cancer
Hoofdauteurs: Peterse, Elisabeth F. P., Niessen, Bertine, Addie, Ruben D., de Jong, Yvonne, Cleven, Arjen H. G., Kruisselbrink, Alwine B., van den Akker, Brendy E. W. M., Molenaar, Remco J., Cleton-Jansen, Anne-Marie, Bovée, Judith V. M. G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931088/
https://ncbi.nlm.nih.gov/pubmed/29576625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0050-9
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