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A haplotype-aware de novo assembly of related individuals using pedigree sequence graph

MOTIVATION: Reconstructing high-quality haplotype-resolved assemblies for related individuals has important applications in Mendelian diseases and population genomics. Through major genomics sequencing efforts such as the Personal Genome Project, the Vertebrate Genome Project (VGP) and the Genome in...

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Vydáno v:Bioinformatics
Hlavní autoři: Garg, Shilpa, Aach, John, Li, Heng, Sebenius, Isaac, Durbin, Richard, Church, George
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7759745/
https://ncbi.nlm.nih.gov/pubmed/31860070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btz942
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